Dab1 (12N1) Rabbit Monoclonal Antibody

Western blot analysis of extracts from Mouse brain tissue using AP93833 at 1:1000.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	P97318
Reactivity	Rat, Mouse
Clonality	Monoclonal
Calculated MW	63578 Da

Additional Information
Gene ID	13131
Other Names	Disabled homolog 1, mDab1, Dab1 {ECO:0000303\|PubMed:9009273, ECO:0000312\|MGI:MGI:108554}
Dilution	WB~~1:1000
Storage Conditions	-20℃

Protein Information
Name	Dab1 {ECO:0000303\|PubMed:9009273, ECO:0000312\|MGI:MGI:108554}
Function	Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development (PubMed:12526739, PubMed:9009273, PubMed:9338784, PubMed:9338785). Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain (PubMed:12526739, PubMed:9009273, PubMed:9338784, PubMed:9338785).
Cellular Location	Cytoplasm.
Tissue Location	Expressed mainly in brain (PubMed:9009273, PubMed:9338785). Specifically expressin in cortical neurons (PubMed:9338784, PubMed:9338785).