癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
STEAP1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- 背景知识
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UHE8 |
| Other Accession | NP_036581.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 39851 Da |
| Antigen Region | 2-31 aa |
| Gene ID | 26872 |
|---|---|
| Other Names | Metalloreductase STEAP1, 1161-, Six-transmembrane epithelial antigen of prostate 1, STEAP1, PRSS24, STEAP |
| Target/Specificity | This STEAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human STEAP1. |
| Dilution | WB~~1:2000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | STEAP1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STEAP1 |
|---|---|
| Synonyms | PRSS24, STEAP |
| Function | Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4. |
| Cellular Location | Endosome membrane {ECO:0000250|UniProtKB:Q9CWR7}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Ubiquitously expressed. Highly expressed in prostate tumors. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions.
REFERENCES
Valenti, M.T., et al. J. Endocrinol. Invest. 33(4):244-249(2010)
Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :
Vaghjiani, R.J., et al. Tissue Eng Part A 15(8):2073-2083(2009)
Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
Maia, C.J., et al. Endocrine 34 (1-3), 108-116 (2008) :
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