癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MBL2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| IHC-P, IF, WB |
|---|---|
| Primary Accession | P11226 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 26144 Da |
| Isotype | Rabbit IgG |
| Antigen Source | HUMAN |
| Gene ID | 4153 |
|---|---|
| Antigen Region | 188-222 aa |
| Other Names | Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin, MBL2, COLEC1, MBL |
| Dilution | IHC-P~~1:100~500 IF~~1:10~50 WB~~1:1000 |
| Target/Specificity | This MBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-222 amino acids from the C-terminal region of human MBL2. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MBL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MBL2 (HGNC:6922) |
|---|---|
| Synonyms | COLEC1, MBL |
| Function | Calcium-dependent lectin involved in innate immune defense (PubMed:35102342). Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342). |
| Cellular Location | Secreted. |
| Tissue Location | Plasma protein produced mainly in the liver. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases.
REFERENCES
Auriti, C., et al. Hum. Immunol. 71(11):1084-1088(2010)
Fraser, D.A., et al. J. Immunol. 185(7):3932-3939(2010)
de Wit, E., et al. Mamm. Genome (2010) In press :
Filho, R.M., et al. Viral Immunol. 23(4):449-453(2010)
Hu, Y., et al. Viral Immunol. 23(4):443-447(2010)
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