癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
VSNL1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant VSNL1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P62760 |
| Other Accession | BC022012 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 2F1-E3 |
| Calculated MW | 22142 Da |
| Gene ID | 7447 |
|---|---|
| Other Names | Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3, VSNL1, VISL1 |
| Target/Specificity | VSNL1 (AAH22012, 1 a.a. ~ 191 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | VSNL1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.
REFERENCES
MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. Xu Y, et al. Schizophr Res, 2010 Jun. PMID 20347265.Visinin-like protein 1 regulates natriuretic peptide receptor B in the heart. Buttgereit J, et al. Regul Pept, 2010 Apr 9. PMID 20079378.Promoter regulation of the visinin-like subfamily of neuronal calcium sensor proteins by nuclear respiratory factor-1. Fu J, et al. J Biol Chem, 2009 Oct 2. PMID 19674972.Regulatory elements and functional implication for the formation of dimeric visinin-like protein-1. Chen KC, et al. J Pept Sci, 2009 Feb. PMID 19065602.Neuronal Ca2+ sensor VILIP-1 leads to the upregulation of functional alpha4beta2 nicotinic acetylcholine receptors in hippocampal neurons. Zhao CJ, et al. Mol Cell Neurosci, 2009 Feb. PMID 19063970.
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