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>   首页   >   产品   >   一抗   >   癌症   >   VSNL1 Antibody (Center)   

VSNL1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - VSNL1 Antibody (Center) AP12201c
    Western blot analysis of VSNL1 (arrow) using rabbit polyclonal VSNL1 Antibody (Center) (Cat. #AP12201c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the VSNL1 gene.
  • 1 - VSNL1 Antibody (Center) AP12201c
    VSNL1 Antibody (Center) (Cat. #AP12201c) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the VSNL1 antibody detected the VSNL1 protein (arrow).
  • 14 - VSNL1 Antibody (Center) AP12201c
    VSNL1 Antibody (Center) (Cat. #AP12201c)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of VSNL1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • 4 - VSNL1 Antibody (Center) AP12201c
    VSNL1 Antibody (Center) (Cat. #AP12201c) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession P62760
Other Accession P62762, P62761, Q4R5F7, P62764, P62763, P35332, Q8BGZ1, Q9UM19, P29104, NP_003376
Reactivity Human, Mouse
Predicted Bovine, Rat, Chicken, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 22142 Da
Antigen Region 47-75 aa
Additional Information
Gene ID 7447
Other Names Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3, VSNL1, VISL1
Target/Specificity This VSNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 47-75 amino acids from the Central region of human VSNL1.
Dilution WB~~1:1000
IHC-P~~1:100~500
FC~~1:10~50
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsVSNL1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name VSNL1
Synonyms VISL1
Function Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner.
Tissue Location Brain and retina. Neuron-specific in the central and peripheral nervous system. Increased in the cerebrospinal fluid of Alzheimer disease patients (at protein level)
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

REFERENCES

Xu, Y., et al. Schizophr. Res. 119 (1-3), 219-227 (2010) :
Buttgereit, J., et al. Regul. Pept. 161 (1-3), 51-57 (2010) :
Fu, J., et al. J. Biol. Chem. 284(40):27577-27586(2009)
Chen, K.C., et al. J. Pept. Sci. 15(2):89-94(2009)
Zhao, C.J., et al. Mol. Cell. Neurosci. 40(2):280-292(2009)

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