癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TPBG Antibody (monoclonal) (M03)
Mouse monoclonal antibody raised against a partial recombinant TPBG.
- 产品详情
- 实验流程
- 背景知识
Application 
| E |
|---|---|
| Primary Accession | Q13641 |
| Other Accession | NM_006670 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2b Kappa |
| Clone Names | 3D6 |
| Calculated MW | 46032 Da |
| Gene ID | 7162 |
|---|---|
| Other Names | Trophoblast glycoprotein, 5T4 oncofetal antigen, 5T4 oncofetal trophoblast glycoprotein, 5T4 oncotrophoblast glycoprotein, M6P1, Wnt-activated inhibitory factor 1, WAIF1, TPBG, 5T4 |
| Target/Specificity | TPBG (NP_006661, 219 a.a. ~ 328 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TPBG Antibody (monoclonal) (M03) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
REFERENCES
An MVA-based vaccine targeting the oncofetal antigen 5T4 in patients undergoing surgical resection of colorectal cancer liver metastases. Elkord E, et al. J Immunother, 2008 Nov-Dec. PMID 18833005.Identification and functional validation of MHC class I epitopes in the tumor-associated antigen 5T4. Shingler WH, et al. Int Immunol, 2008 Aug. PMID 18567615.Placenta-derived, cellular messenger RNA expression in the maternal blood of preeclamptic women. Okazaki S, et al. Obstet Gynecol, 2007 Nov. PMID 17978129.CD8 T-cell recognition of human 5T4 oncofetal antigen. Smyth LJ, et al. Int J Cancer, 2006 Oct 1. PMID 16646078.Cell surface 5T4 antigen is transiently upregulated during early human embryonic stem cell differentiation: effect of 5T4 phenotype on neural lineage formation. Ward CM, et al. Exp Cell Res, 2006 Jun 10. PMID 16616918.
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