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>   首页   >   产品   >   重组兔单克隆抗体   >   重组兔单克隆抗体   >   5T4 Antibody   

5T4 Antibody

Rabbit mAb

     
  • 1 - 5T4 Antibody AP90363
    Western blot analysis of 5T4 expression in MCF-7 cell lysate.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IP
Primary Accession Q13641
Reactivity Rat, Human, Mouse
Clonality Monoclonal
Other Names 5T4; 5T4AG; M6P1; TPBG; 5T4 oncofetal antigen;Trophoblast glycoprotein;
Isotype Rabbit IgG
Host Rabbit
Calculated MW 46032 Da
Additional Information
Dilution WB 1:500~1:2000 IP 1:50
Purification Affinity-chromatography
Immunogen A synthesized peptide derived from human 5T4
Description 5T4 is a 72 kDa transmembrane glycoprotein that exhibits restricted expression in human and mouse adult tissues, is upregulated on many carcinomas and tumour expression correlates with poorer clinical outcome in ovarian, gastric and colorectal cancers. mES cells lack cell surface expression of the 5T4 antigen, and both protein and mRNA are rapidly upregulated following induction of differentiation. This proteins expression correlates with downregulation of OCT-4 and Tra-1–60.
Storage Condition and Buffer Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Protein Information
Name TPBG
Synonyms 5T4
Function May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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