癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TLN1 Antibody (monoclonal) (M05)
Mouse monoclonal antibody raised against a partial recombinant TLN1.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, E |
|---|---|
| Primary Accession | Q9Y490 |
| Other Accession | NM_006289 |
| Reactivity | Human, Mouse, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG3 Kappa |
| Clone Names | 5C1 |
| Calculated MW | 269767 Da |
| Gene ID | 7094 |
|---|---|
| Other Names | Talin-1, TLN1, KIAA1027, TLN |
| Target/Specificity | TLN1 (NP_006280, 1052 a.a. ~ 1149 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | TLN1 Antibody (monoclonal) (M05) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin.
REFERENCES
Zap70 controls the interaction of talin with integrin to regulate the chemotactic directionality of T-cell migration. Lin YP, et al. Mol Immunol, 2010 Jul. PMID 20488542.Talin1 promotes tumor invasion and metastasis via focal adhesion signaling and anoikis resistance. Sakamoto S, et al. Cancer Res, 2010 Mar 1. PMID 20160039.Functional and structural characterization of the talin F0F1 domain. Domadia PN, et al. Biochem Biophys Res Commun, 2010 Jan 1. PMID 19903453.GATA-1, G208S macrothrombocytes are deficient in talin: immunofluorescence studies. White JG, et al. Platelets, 2009 May. PMID 19437340.Dystrophin-glycoprotein complex and vinculin-talin-integrin system in human adult cardiac muscle. Anastasi G, et al. Int J Mol Med, 2009 Feb. PMID 19148538.
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