癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SFN Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full-length recombinant SFN.
- 产品详情
- 实验流程
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P31947 |
| Other Accession | BC000329 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 2G2 |
| Other Names | 14-3-3 protein sigma, Epithelial cell marker protein 1, Stratifin, SFN, HME1 |
|---|---|
| Target/Specificity | SFN (AAH00329.1, 1 a.a. ~ 248 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | SFN Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis. Zurita M, et al. BMC Cancer, 2010 May 20. PMID 20487521.The expression of seven 14-3-3 isoforms in human meningioma. Liu Y, et al. Brain Res, 2010 Jun 8. PMID 20388496.[Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer] Pei HP, et al. Zhonghua Wei Chang Wai Ke Za Zhi, 2010 Mar. PMID 20336542.Reduced stratifin expression can serve as an independent prognostic factor for poor survival in patients with esophageal squamous cell carcinoma. Ren HZ, et al. Dig Dis Sci, 2010 Sep. PMID 20108042.Up-regulation of 14-3-3sigma (Stratifin) is associated with high-grade CIN and high-risk human papillomavirus (HPV) at baseline but does not predict outcomes of HR-HPV infections or incident CIN in the LAMS study. Syrj?nen S, et al. Am J Clin Pathol, 2010 Feb. PMID 20093232.
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