癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RNF41 Antibody (monoclonal) (M01A)
Mouse monoclonal antibody raised against a partial recombinant RNF41.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9H4P4 |
| Other Accession | NM_005785 |
| Reactivity | Human, Rat |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgM Kappa |
| Clone Names | 4C2 |
| Calculated MW | 35905 Da |
| Gene ID | 10193 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase NRDP1, 632-, RING finger protein 41, RNF41, FLRF, NRDP1 |
| Target/Specificity | RNF41 (NP_005776, 218 a.a. ~ 317 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | RNF41 Antibody (monoclonal) (M01A) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.
REFERENCES
Nrdp1-mediated regulation of ErbB3 expression by the androgen receptor in androgen-dependent but not castrate-resistant prostate cancer cells. Chen L, et al. Cancer Res, 2010 Jul 15. PMID 20587519.Apollon/RNF41 myocardial messenger RNA diagnoses cardiac allograft apoptosis in rejection. Aharinejad S, et al. Transplantation, 2010 Jan 27. PMID 20098290.Genetic screening for mutations in the Nrdp1 gene in Parkinson disease patients in a Chinese population. Mo X, et al. Parkinsonism Relat Disord, 2010 Mar. PMID 19800834.Parkin is ubiquitinated by Nrdp1 and abrogates Nrdp1-induced oxidative stress. Yu F, et al. Neurosci Lett, 2008 Jul 25. PMID 18541373.Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Cao Z, et al. Mol Cell Biol, 2007 Mar. PMID 17210635.
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