癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
RNF41 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, E |
|---|---|
| Primary Accession | Q9H4P4 |
| Other Accession | Q5FWL3, Q8BH75, Q7ZW16, NP_005776.1 |
| Reactivity | Human |
| Predicted | Zebrafish, Mouse, Xenopus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 35905 Da |
| Antigen Region | 255-281 aa |
| Gene ID | 10193 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase NRDP1, 632-, RING finger protein 41, RNF41, FLRF, NRDP1 |
| Target/Specificity | This RNF41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-281 amino acids from the C-terminal region of human RNF41. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RNF41 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RNF41 |
|---|---|
| Synonyms | FLRF, NRDP1 |
| Function | Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). |
| Tissue Location | Detected in ovary, testis and prostate. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq].
REFERENCES
Ingalla, E.Q., et al. J. Biol. Chem. 285(37):28691-28697(2010)
Chen, L., et al. Cancer Res. 70(14):5994-6003(2010)
Mo, X., et al. Parkinsonism Relat. Disord. 16(3):222-224(2010)
Aharinejad, S., et al. Transplantation 89(2):245-252(2010)
Yu, F., et al. Neurosci. Lett. 440(1):4-8(2008)
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