癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
POU4F3 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant POU4F3.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | Q15319 |
| Other Accession | NM_002700 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 5B8 |
| Calculated MW | 37052 Da |
| Gene ID | 5459 |
|---|---|
| Other Names | POU domain, class 4, transcription factor 3, Brain-specific homeobox/POU domain protein 3C, Brain-3C, Brn-3C, POU4F3, BRN3C |
| Target/Specificity | POU4F3 (NP_002691, 100 a.a. ~ 190 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | POU4F3 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15.
REFERENCES
A novel frameshift mutation of POU4F3 gene associated with autosomal dominant non-syndromic hearing loss. Lee HK, et al. Biochem Biophys Res Commun, 2010 Jun 4. PMID 20434433.Molecular modelling insights into DFNA15 mediated enhancement of POU4F3 stability. Frenz CM, et al. Int J Comput Biol Drug Des, 2008. PMID 20054994.Mild and variable audiometric and vestibular features in a third DFNA15 family with a novel mutation in POU4F3. de Heer AM, et al. Ann Otol Rhinol Laryngol, 2009 Apr. PMID 19462854.Vestibular impairment in a Dutch DFNA15 family with an L289F mutation in POU4F3. van Drunen FJ, et al. Audiol Neurootol, 2009. PMID 19372648.Audiometric characteristics of a Dutch family linked to DFNA15 with a novel mutation (p.L289F) in POU4F3. Pauw RJ, et al. Arch Otolaryngol Head Neck Surg, 2008 Mar. PMID 18347256.
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