癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
MBNL1 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant MBNL1.
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NR56 |
| Other Accession | BC050535 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1D11 |
| Calculated MW | 41817 Da |
| Gene ID | 4154 |
|---|---|
| Other Names | Muscleblind-like protein 1, Triplet-expansion RNA-binding protein, MBNL1, EXP, KIAA0428, MBNL |
| Target/Specificity | MBNL1 (AAH50535, 1 a.a. ~ 343 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | MBNL1 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. Sen S, et al. J Biol Chem, 2010 Aug 13. PMID 20519504.A simple ligand that selectively targets CUG trinucleotide repeats and inhibits MBNL protein binding. Arambula JF, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805260.Ribonuclear inclusions and MBNL1 nuclear sequestration do not affect myoblast differentiation but alter gene splicing in myotonic dystrophy type 2. Cardani R, et al. Neuromuscul Disord, 2009 May. PMID 19345584.Muscleblind-like proteins: similarities and differences in normal and myotonic dystrophy muscle. Holt I, et al. Am J Pathol, 2009 Jan. PMID 19095965.Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Teplova M, et al. Nat Struct Mol Biol, 2008 Dec. PMID 19043415.
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