癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CYGB Antibody (monoclonal) (M02)
Mouse monoclonal antibody raised against a full length recombinant CYGB.
- 产品详情
- 文献引用 : 1
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, E |
|---|---|
| Primary Accession | Q8WWM9 |
| Other Accession | BC029798 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG1 Kappa |
| Clone Names | 1A1 |
| Calculated MW | 21405 Da |
| Gene ID | 114757 |
|---|---|
| Other Names | Cytoglobin, Histoglobin, HGb, Stellate cell activation-associated protein, CYGB, STAP |
| Target/Specificity | CYGB (AAH29798, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CYGB Antibody (monoclonal) (M02) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress (Trent and Hargrove, 2002 [PubMed 11893755]).
REFERENCES
1.Cytoglobin has bimodal: tumour suppressor and oncogene functions in lung cancer cell lines.Oleksiewicz U, Liloglou T, Tasopoulou KM, Daskoulidou N, Bryan J, Gosney JR, Field JK, Xinarianos GHum Mol Genet. 2013 Apr 24.2.Pathway specific gene expression profiling reveals oxidative stress genes potentially regulated by transcription co-activator LEDGF/p75 in prostate cancer cells.Basu A, Drame A, Munoz R, Gijsbers R, Debyser Z, De Leon M, Casiano CA.Prostate. 2011 Jul 27. doi: 10.1002/pros.21463. [Epub ahead of print]3.p53-mediated apoptosis, neuroglobin overexpression, and globin deposits in a patient with hereditary ferritinopathy.Powers JM.J Neuropathol Exp Neurol. 2006 Jul;65(7):716-21.4.Hypoxia differentially regulates the expression of neuroglobin and cytoglobin in rat brain.Li RC, Lee SK, Pouranfar F, Brittian KR, Clair HB, Row BW, Wang Y, Gozal D.Brain Res. 2006 Jun 22;1096(1):173-9. Epub 2006 Jun 5.
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