癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CYGB Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a full length recombinant CYGB.
- 产品详情
- 实验流程
- 背景知识
Application 
| IF |
|---|---|
| Primary Accession | Q8WWM9 |
| Other Accession | BC029798 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a kappa |
| Clone Names | 3A5-2D2 |
| Calculated MW | 21405 Da |
| Gene ID | 114757 |
|---|---|
| Other Names | Cytoglobin, Histoglobin, HGb, Stellate cell activation-associated protein, CYGB, STAP |
| Target/Specificity | CYGB (AAH29798, 1 a.a. ~ 190 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | IF~~1:50~200 |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CYGB Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Cytoglobin is a ubiquitously expressed hexacoordinate hemoglobin that may facilitate diffusion of oxygen through tissues, scavenge nitric oxide or other reactive oxygen species, or serve a protective function during oxidative stress (Trent and Hargrove, 2002 [PubMed 11893755]).
REFERENCES
Cytoglobin conformations and disulfide bond formation. Lechauve C, et al. FEBS J, 2010 Jun. PMID 20553503.Nitric-oxide dioxygenase function of human cytoglobin with cellular reductants and in rat hepatocytes. Gardner AM, et al. J Biol Chem, 2010 Jul 30. PMID 20511233.Cytoglobin is upregulated by tumour hypoxia and silenced by promoter hypermethylation in head and neck cancer. Shaw RJ, et al. Br J Cancer, 2009 Jul 7. PMID 19568272.Cytoglobin is expressed in the vasculature and regulates cell respiration and proliferation via nitric oxide dioxygenation. Halligan KE, et al. J Biol Chem, 2009 Mar 27. PMID 19147491.Patterns of distribution of oxygen-binding globins, neuroglobin and cytoglobin in human retina. Ostoji? J, et al. Arch Ophthalmol, 2008 Nov. PMID 19001220.
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