癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CLDN2 Antibody (monoclonal) (M01)
Mouse monoclonal antibody raised against a partial recombinant CLDN2.
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P57739 |
| Other Accession | NM_020384 |
| Reactivity | Human |
| Host | mouse |
| Clonality | monoclonal |
| Isotype | IgG2a Kappa |
| Clone Names | 3F1 |
| Calculated MW | 24549 Da |
| Gene ID | 9075 |
|---|---|
| Other Names | Claudin-2, SP82, CLDN2 |
| Target/Specificity | CLDN2 (NP_065117, 29 a.a. ~ 80 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
| Dilution | WB~~1:500~1000 E~~N/A |
| Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
| Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
| Precautions | CLDN2 Antibody (monoclonal) (M01) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
REFERENCES
1.A novel microfluidics-based method for probing weak protein-protein interactions.Tan DC, Wijay IP, Ochsner M, Vasina EN, Nallani M, Hunziker W, Kathrin-Sinner E.Lab Chip, 2012 DOI: 10.1039/C2LC40228A2.Proteopolymersomes: In vitro production of a membrane protein in polymersome membranes.Nallani M, Andreasson-Ochsner M, Darren Tan CW, Sinner EK, Wisantoso Y, Geifman-Shochat S, Hunziker W.Biointerphases 6, 153 (2011); doi:10.1116/ 1.36443843.Probing Effects of pH change on Dynamic Response of Claudin-2 Mediated Adhesion Using Single Molecule Force Spectroscopy.Lim TS, Vedula SR, Huic S, Kausalya PJ, Hunzikerd W, Lim CT.Exp Cell Res. 2008 Aug 15;314(14):2643-51. Epub 2008 Jun 3.
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