ABL2 Antibody (monoclonal) (M09)
Mouse monoclonal antibody raised against a partial recombinant ABL2.
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| WB, IHC, IF, E |
---|---|
Primary Accession | P42684 |
Other Accession | BC065912 |
Reactivity | Human |
Host | mouse |
Clonality | monoclonal |
Isotype | IgG3 Kappa |
Clone Names | 5C6 |
Calculated MW | 128343 Da |
Gene ID | 27 |
---|---|
Other Names | Abelson tyrosine-protein kinase 2, Abelson murine leukemia viral oncogene homolog 2, Abelson-related gene protein, Tyrosine-protein kinase ARG, ABL2, ABLL, ARG |
Target/Specificity | ABL2 (AAH65912, 743 a.a. ~ 842 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. |
Dilution | WB~~1:500~1000 IHC~~1:100~500 IF~~1:50~200 E~~N/A |
Format | Clear, colorless solution in phosphate buffered saline, pH 7.2 . |
Storage | Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing. |
Precautions | ABL2 Antibody (monoclonal) (M09) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.
REFERENCES
Variation at the NFATC2 Locus Increases the Risk of Thiazolinedinedione-Induced Edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) Study. Bailey SD, et al. Diabetes Care, 2010 Jul 13. PMID 20628086.Successful treatment using omacetaxine for a patient with CML and BCR-ABL1 [corrected] 35INS. Mahadeo KM, et al. Blood, 2010 May 6. PMID 20448119.NMR structure of F-actin-binding domain of Arg/Abl2 from Homo sapiens. Liu G, et al. Proteins, 2010 Apr. PMID 20077570.Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.Reciprocal regulation of Abl and receptor tyrosine kinases. Srinivasan D, et al. Cell Signal, 2009 Jul. PMID 19275932.

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