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>   首页   >   产品   >   一抗   >   精选抗体   >   Anti-CHI3L1 Reference Antibody (Brown U. patent anti-CHI3L1)   

Anti-CHI3L1 Reference Antibody (Brown U. patent anti-CHI3L1)

Recombinant Antibody

     
  • 1 - Anti-CHI3L1 Reference Antibody (Brown U. patent anti-CHI3L1) APR10830
    Anti-CHI3L1 Reference Antibody (Brown U. patent anti-CHI3L1) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%
  • 1 - Anti-CHI3L1 Reference Antibody (Brown U. patent anti-CHI3L1) APR10830
    The purity of Anti-CHI3L1 Reference Antibody (Brown U. patent anti-CHI3L1)is more than 95% ,determined by SEC-HPLC.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession P36222
Reactivity Human
Clonality Monoclonal
Isotype IgG1
Calculated MW 42625 Da
Additional Information
Target/Specificity CHI3L1
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name CHI3L1
Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia- induced injury, inflammation and epithelial apoptosis in lung.
Cellular Location Secreted, extracellular space. Cytoplasm. Cytoplasm, perinuclear region. Endoplasmic reticulum
Tissue Location Present in activated macrophages, articular chondrocytes, synovial cells as well as in liver. Very low or undetectable expression in non-inflammatory colon. Undetectable in muscle tissues, lung, pancreas, mononuclear cells, or fibroblasts
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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