Anti-CALCA / CGRP Reference Antibody (fremanezumab)
Recombinant Antibody
- 产品详情
- 实验流程
Application ![]()
| FC, Kinetics, Animal Model |
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Primary Accession | P06881 |
Reactivity | Human |
Clonality | Monoclonal |
Isotype | IgG2SA |
Calculated MW | 13899 Da |
Target/Specificity | CALCA / CGRP |
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Endotoxin | < 0.001EU/ µg,determined by LAL method. |
Conjugation | Unconjugated |
Expression system | CHO Cell |
Format | Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column. |
Name | CALCA (HGNC:1437) |
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Synonyms | CALC1 |
Function | CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770). |
Cellular Location | Secreted. |
Tissue Location | Expressed in spinal cord. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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