C1orf173 Rabbit pAb
C1orf173 Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| IHC-P, IHC-F, IF |
---|---|
Primary Accession | Q5RHP9 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 168466 Da |
Physical State | Liquid |
Immunogen | KLH conjugated synthetic peptide derived from human C1orf173 |
Epitope Specificity | 301-400/1530 |
Isotype | IgG |
Purity | affinity purified by Protein A |
Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Background Descriptions | Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf173 gene product has been provisionally designated C1orf173 pending further characterization. There are three isoforms of C1orf173 that are produced as a result of alternative splicing events. |
Gene ID | 127254 |
---|---|
Other Names | Glutamate-rich protein 3, ERICH3 (HGNC:25346), C1orf173 |
Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Name | ERICH3 (HGNC:25346) |
---|---|
Synonyms | C1orf173 |
Function | Component of the primary cilium that controls cilium formation and length (PubMed:31712586). May function within retrograde intraflagellar transport (IFT)-associated pathways to remove signaling proteins from primary cilia (PubMed:31712586). Also involved in neuronal vesicle biogenesis and neurotransmitter vesicular function (PubMed:33230203). |
Cellular Location | Cell projection, cilium. Cytoplasm Note=Located in primary cilia, with enriched localization along the entire ciliary axoneme (PubMed:31712586). Localized to the cytoplasm in neurons and appears to be vesicle-associated (PubMed:33230203) |
Tissue Location | Expressed in dopaminergic and serotoninergic neurons. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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