ASH1L Rabbit pAb
ASH1L Rabbit pAb
- 产品详情
- 实验流程
- 背景知识
Application ![]()
| IHC-P, IHC-F, IF |
---|---|
Primary Accession | Q9NR48 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 332790 Da |
Physical State | Liquid |
Immunogen | KLH conjugated synthetic peptide derived from human ASH1L |
Epitope Specificity | 1985-2060/2969 |
Isotype | IgG |
Purity | affinity purified by Protein A |
Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
SUBCELLULAR LOCATION | Nucleus. Cell junction, tight junction. Chromosome (Probable). Note=The relevance of tight junction localization is however unclear. |
SIMILARITY | Belongs to the histone-lysine methyltransferase family. SET2 subfamily. Contains 3 A.T hook DNA-binding domains.Contains 1 AWS domain. Contains 1 BAH domain. Contains 1 bromo domain. Contains 1 PHD-type zinc finger. Contains 1 post-SET domain. Contains 1 SET domain. |
Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
Background Descriptions | ASH1L is a 2,969 amino acid protein encoded by the human gene ASH1L. ASH1L belongs to the histone-lysine methyltransferase family (SET2 subfamily) and contains three AT hook DNA-binding domains, one AWS domain, one BAH domain, one bromodomain, one PHD-type zinc finger, one post-SET domain and one SET domain. It is a widely expressed nuclear protein with highest expression found in brain, heart and kidney. ASH1L is a histone methyltransferase and is believed to methylate 'Lys-4' of Histone H3, which is a specific tag for epigenetic transcriptional activation. |
Gene ID | 55870 |
---|---|
Other Names | Histone-lysine N-methyltransferase ASH1L, 2.1.1.359, 2.1.1.367, ASH1-like protein, huASH1, Absent small and homeotic disks protein 1 homolog, Lysine N-methyltransferase 2H, ASH1L, KIAA1420, KMT2H |
Target/Specificity | Widely expressed, with highest level in brain, heart and kidney. |
Dilution | IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500 |
Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
Name | ASH1L |
---|---|
Synonyms | KIAA1420, KMT2H |
Function | Histone methyltransferase specifically trimethylating 'Lys- 36' of histone H3 forming H3K36me3 (PubMed:21239497). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro (By similarity). The physiological significance of the H3K9me1 activity is unclear (By similarity). |
Cellular Location | Nucleus. Cell junction, tight junction. Chromosome. Note=The relevance of tight junction localization is however unclear. |
Tissue Location | Widely expressed, with highest level in brain, heart and kidney. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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