癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
KDM3A (8K18) Rabbit Monoclonal Antibody
KDM3A (8K18) Rabbit Monoclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC, IF, FC, ICC, IP |
|---|---|
| Primary Accession | Q9Y4C1, Q6PCM1, Q63679 |
| Reactivity | Rat, Human, Mouse |
| Clonality | Monoclonal |
| Calculated MW | 147341 Da |
| Gene ID | 55818 |
|---|---|
| Dilution | WB~~1:1000 IHC~~1:100~500 IF~~1:50~200 FC~~1:10~50 ICC~~N/A IP~~N/A |
| Storage Conditions | -20℃ |
| Name | KDM3A |
|---|---|
| Synonyms | JHDM2A, JMJD1, JMJD1A, KIAA0742, TSGA |
| Function | Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. |
| Cellular Location | Cytoplasm. Nucleus. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
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