CDC5 (16S9) Rabbit Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC, IF, ICC
Primary Accession	Q99459
Reactivity	Rat, Human, Mouse
Clonality	Monoclonal
Calculated MW	92251 Da

Additional Information
Gene ID	988
Other Names	Cell division cycle 5-like protein, Cdc5-like protein, Pombe cdc5-related protein, CDC5L, KIAA0432, PCDC5RP
Dilution	WB~~1:1000 IHC~~1:100~500 IF~~1:50~200 ICC~~N/A
Storage Conditions	-20℃

Protein Information
Name	CDC5L
Synonyms	KIAA0432, PCDC5RP
Function	DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes (PubMed:11991638, PubMed:20176811, PubMed:28076346, PubMed:28502770, PubMed:29301961, PubMed:29360106, PubMed:29361316, PubMed:30705154, PubMed:30728453). Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR) (PubMed:20176811). As a component of the minor spliceosome, involved in the splicing of U12- type introns in pre-mRNAs (Probable).
Cellular Location	Nucleus. Nucleus speckle. Cytoplasm Note=May shuttle between cytoplasm and nucleus
Tissue Location	Ubiquitously expressed in both fetal and adult tissues.