CHMP7 Rabbit Polyclonal Antibody

Western blot analysis of lysates from VEC cells, primary antibody was diluted at 1:1000, 4°over night

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	Q8WUX9
Reactivity	Human, Mouse
Host	Polyclonal, Rabbit,IgG
Clonality	Polyclonal
Calculated MW	50911 Da

Additional Information
Gene ID	91782
Other Names	Charged multivesicular body protein 7, Chromatin-modifying protein 7, CHMP7
Dilution	WB~~1:1000
Storage Conditions	-20℃

Protein Information
Name	CHMP7
Function	ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope (NE) during late anaphase (PubMed:26040712). Together with SPAST, the ESCRT-III complex promotes NE sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712, PubMed:28242692). Recruited to the reforming NE during anaphase by LEMD2 (PubMed:28242692). Plays a role in the endosomal sorting pathway (PubMed:16856878).
Cellular Location	Cytoplasm. Nucleus envelope. Nucleus envelope. Note=Diffused localization, with some punctate distribution, especially in the perinuclear area (PubMed:16856878). Localizes to the reforming nuclear envelope on chromatin disks during late anaphase (PubMed:26040712, PubMed:28242692).