癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
EYS Rabbit Polyclonal Antibody
EYS Rabbit Polyclonal Antibody
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- 背景知识
Application 
| IHC, IF |
|---|---|
| Primary Accession | Q5T1H1 |
| Reactivity | Rat, Human, Mouse |
| Host | Polyclonal, Rabbit,IgG |
| Clonality | Polyclonal |
| Calculated MW | 350796 Da |
| Gene ID | 346007 |
|---|---|
| Other Names | Protein eyes shut homolog, Epidermal growth factor-like protein 10, EGF-like protein 10, Epidermal growth factor-like protein 11, EGF-like protein 11, Protein spacemaker homolog, EYS, C6orf178, C6orf179, C6orf180, EGFL10, EGFL11, SPAM |
| Dilution | IHC~~1:100~500 IF~~1:50~200 |
| Storage Conditions | -20℃ |
| Name | EYS |
|---|---|
| Synonyms | C6orf178, C6orf179, C6orf180, EGFL10, EG |
| Function | Required to maintain the integrity of photoreceptor cells (PubMed:18836446). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity). |
| Cellular Location | Cell projection, cilium, photoreceptor outer segment. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Localizes to discrete puncta at, or adjacent to, the photoreceptor connecting cilium (PubMed:27737822) Highly expressed in cone photoreceptor outer segments (PubMed:27737822). Weakly expressed in rod photoreceptor outer segments (By similarity). May localize to the cilium axoneme (PubMed:27846257) May also be secreted into the interphotoreceptor extracellular matrix (PubMed:27737822). {ECO:0000250|UniProtKB:A0A2K5V015, ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:27846257} |
| Tissue Location | Expressed in retina (at protein level) (PubMed:18836446, PubMed:18976725, PubMed:27737822, PubMed:27846257) Isoform 1: Detected in retina (PubMed:27846257). Isoform 2: Detected in retina (PubMed:27846257). Isoform 3: Strongly expressed in retina and testis (PubMed:27846257). Isoform 4: Strongly expressed in testis, and weakly expressed in retina (PubMed:27846257) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The product of this gene contains multiple epidermal growth factor (EGF)-like and LamG domains. The protein is expressed in the photoreceptor layer of the retina, and the gene is mutated in autosomal recessive retinitis pigmentosa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008],
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