PRAP1 Rabbit Polyclonal Antibody

Western blot analysis of lysates from HpeG2 cells, primary antibody was diluted at 1:1000, 4°over night

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	Q96NZ9
Reactivity	Rat, Human, Mouse
Host	Polyclonal, Rabbit,IgG
Clonality	Polyclonal
Calculated MW	17208 Da

Additional Information
Gene ID	118471
Other Names	Proline-rich acidic protein 1, Epididymis tissue protein Li 178, Uterine-specific proline-rich acidic protein, PRAP1, UPA
Dilution	WB~~1:1000
Storage Conditions	-20℃

Protein Information
Name	PRAP1
Synonyms	UPA
Function	Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459). Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459). May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861).
Cellular Location	Secreted. Endoplasmic reticulum {ECO:0000250\|UniProtKB:Q80XD8}
Tissue Location	Highly expressed in the intestinal epithelial cells (at protein level) (PubMed:32629119). Abundantly expressed in the epithelial cells of the liver, kidney and cervix. Significantly down- regulated in hepatocellular carcinoma and right colon adenocarcinoma compared with the respective adjacent normal tissues. Expressed in epididymis (at protein level).