癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
ENTPD2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC-P, FC, E |
|---|---|
| Primary Accession | Q9Y5L3 |
| Reactivity | Human, Rat, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 53665 Da |
| Antigen Region | 86-113 aa |
| Gene ID | 954 |
|---|---|
| Other Names | Ectonucleoside triphosphate diphosphohydrolase 2, NTPDase 2, 361-, CD39 antigen-like 1, Ecto-ATP diphosphohydrolase 2, Ecto-ATPDase 2, Ecto-ATPase 2, ENTPD2, CD39L1 |
| Target/Specificity | This ENTPD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-113 amino acids from the N-terminal region of human ENTPD2. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 FC~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ENTPD2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ENTPD2 (HGNC:3364) |
|---|---|
| Function | Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). This activity contributes to the regulation of extracellular nucleotides levels (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (By similarity). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). All nucleoside 5'- diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (By similarity). |
| Cellular Location | [Isoform Long]: Cell membrane; Multi-pass membrane protein [Isoform gamma]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas (PubMed:9271669). No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes (PubMed:9271669) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ENTPD2 is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein.
REFERENCES
Chiang,W.C. Biochemistry 47 (33), 8775-8785 (2008)
Javed,R. Biochemistry 46 (22), 6617-6627 (2007)
Mukasa,T.Biochemistry 44 (33), 11160-11170 (2005)
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