癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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ENTPD2 Rabbit pAb
ENTPD2 Rabbit pAb
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q9Y5L3 |
| Reactivity | Rat |
| Predicted | Human, Mouse, Chicken, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53665 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human ENTPD2/CD39L1 |
| Epitope Specificity | 401-495/495 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Membrane; Multi-pass membrane protein |
| SIMILARITY | Belongs to the GDA1/CD39 NTPase family. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENP1), is an integral membrane glycoprotein that acts as an extracellular nucleotide-hydrolyzing enzyme. CD39 inhibits ADP-induced platelet aggregation by hydrolyzing ADP to AMP and ultimately generating adenosine. Intracellular CD39 undergoes glycosylation at 6 N-glycosylation sites and translocates to the membrane in order to be an active enzyme. CD39L1 is a 495 amino acid multi-pass membrane protein that requires calcium and magnesium cofactors to hydrolyze ATP and other nucleotides in the regulation of purigenic neurotransmission. CD39L1 is expressed in kidney, colon, heart, testis, pancreas, brain, prostate, skeletal muscle, small intestine and ovaries. There are two isoforms of CD39L1 that are produced as a result of alternative splicing events. |
| Gene ID | 954 |
|---|---|
| Other Names | Ectonucleoside triphosphate diphosphohydrolase 2, NTPDase 2, 3.6.1.-, CD39 antigen-like 1, Ecto-ATP diphosphohydrolase 2, Ecto-ATPDase 2, Ecto-ATPase 2, ENTPD2, CD39L1 |
| Target/Specificity | Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas. No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes. |
| Dilution | WB=1:500-2000 |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | ENTPD2 (HGNC:3364) |
|---|---|
| Function | Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). This activity contributes to the regulation of extracellular nucleotides levels (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (By similarity). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). All nucleoside 5'- diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (By similarity). |
| Cellular Location | [Isoform Long]: Cell membrane; Multi-pass membrane protein [Isoform gamma]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Brain, placenta, skeletal muscle, kidney, pancreas, heart, ovary, testis, colon, small intestine, prostate and pancreas (PubMed:9271669). No expression in adult thymus, spleen, lung, liver and peripheral blood leukocytes (PubMed:9271669) |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
CD39, also known as ectonucleoside triphosphate diphosphohydrolase 1 (ENP1), is an integral membrane glycoprotein that acts as an extracellular nucleotide-hydrolyzing enzyme. CD39 inhibits ADP-induced platelet aggregation by hydrolyzing ADP to AMP and ultimately generating adenosine. Intracellular CD39 undergoes glycosylation at 6 N-glycosylation sites and translocates to the membrane in order to be an active enzyme. CD39L1 is a 495 amino acid multi-pass membrane protein that requires calcium and magnesium cofactors to hydrolyze ATP and other nucleotides in the regulation of purigenic neurotransmission. CD39L1 is expressed in kidney, colon, heart, testis, pancreas, brain, prostate, skeletal muscle, small intestine and ovaries. There are two isoforms of CD39L1 that are produced as a result of alternative splicing events.
REFERENCES
Chadwick B.P.,et al.Mamm. Genome 8:668-672(1997).
Mateo J.,et al.Br. J. Pharmacol. 128:396-402(1999).
Mukasa T.,et al.Biochemistry 44:11160-11170(2005).
Humphray S.J.,et al.Nature 429:369-374(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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