癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Desmoplakin Antibody
Rabbit mAb
- 产品详情
- 实验流程
Application 
| WB, IF, FC, ICC |
|---|---|
| Primary Accession | P15924 |
| Reactivity | Rat, Human |
| Clonality | Monoclonal |
| Other Names | Desmoplakin I; Desmoplakin II; DPI; DPII; DSP; KPPS2; PPKS2; |
| Isotype | Rabbit IgG |
| Host | Rabbit |
| Calculated MW | 331774 Da |
| Dilution | WB 1:500~1:2000 ICC/IF 1:50~1:200 FC 1:50 |
|---|---|
| Purification | Affinity-chromatography |
| Immunogen | A synthesized peptide derived from human Desmoplakin |
| Description | Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. |
| Storage Condition and Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle. |
| Name | DSP |
|---|---|
| Function | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). |
| Cellular Location | Cell junction, desmosome. Cell membrane {ECO:0000250|UniProtKB:E9Q557}. Cytoplasm. Note=Localizes to desmosome precursor particles in the cytoplasm (PubMed:25208567). Localizes to the cytoplasm in undifferentiated keratinocytes however becomes localizes to both lateral and tricellular cell-cell contacts as differentiation progresses and as epithelial sheet formation completes (By similarity) {ECO:0000250|UniProtKB:E9Q557, ECO:0000269|PubMed:25208567} |
| Tissue Location | Expressed in oral mucosa (at protein level) (PubMed:30479852). Expressed in arrector pili muscle (at protein level) (PubMed:29034528). Expressed in the heart in the heart (at protein level) (PubMed:18662195). [Isoform DPII]: Resides predominantly in tissues and cells of stratified origin |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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