CD59 Rabbit mAb
- 产品详情
- 实验流程
Application ![]()
| WB, IF, FC, ICC, IP |
---|---|
Primary Accession | P13987 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal Antibody |
Isotype | IgG |
Conjugate | Unconjugated |
Immunogen | A synthesized peptide derived from human CD59 |
Purification | Affinity Chromatography |
Calculated MW | 14177 Da |
Gene ID | 966 |
---|---|
Other Names | CD59 |
Dilution | WB~~1/500-1/1000 IF~~1/50-1/200 FC~~1:10~50 ICC~~N/A IP~~N/A |
Format | Liquid in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol. |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Name | CD59 {ECO:0000303|PubMed:2475570, ECO:0000312|HGNC:HGNC:1689} |
---|---|
Function | Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260). |
Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Localizes to the cell surface (PubMed:36797260). Soluble form found in a number of tissues (PubMed:8670172). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.

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Cat# AP77638