Growth Hormone Receptor Rabbit mAb

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IP
Primary Accession	P10912
Reactivity	Rat
Host	Rabbit
Clonality	Monoclonal Antibody
Calculated MW	71500 Da

Additional Information
Gene ID	2690
Other Names	GHR
Dilution	WB~~1/500-1/1000 IP~~N/A
Format	50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Protein Information
Name	GHR
Function	Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth (PubMed:1549776, PubMed:2825030, PubMed:8943276). On ligand binding, couples to the JAK2/STAT5 pathway (PubMed:1549776, PubMed:15690087, PubMed:2825030, PubMed:8943276).
Cellular Location	Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway {ECO:0000250\|UniProtKB:P19941} [Growth hormone-binding protein]: Secreted. Note=Complexed to a substantial fraction of circulating GH.
Tissue Location	Expressed in various tissues with high expression in liver and skeletal muscle. [Isoform 4]: Predominantly expressed in kidney, bladder, adrenal gland and brain stem (PubMed:1569971). Highly expressed in placental villi (PubMed:1569971, PubMed:8360189)