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CD152 Polyclonal Antibody

     
  • 14 - CD152 Polyclonal Antibody AP74116
    Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
  • 14 - CD152 Polyclonal Antibody AP74116
    Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
  • 14 - CD152 Polyclonal Antibody AP74116
    Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P
Primary Accession P16410
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 24656 Da
Additional Information
Gene ID 1493
Other Names Cytotoxic T-lymphocyte protein 4 (Cytotoxic T-lymphocyte-associated antigen 4) (CTLA-4) (CD antigen CD152)
Dilution IHC-P~~IHC-p 1:50-200, ELISA 1:10000-20000
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name CTLA4
Synonyms CD152
Function Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Cellular Location Cell membrane; Single-pass type I membrane protein. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalization
Tissue Location Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

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