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NTCP Polyclonal Antibody

     
  • 1 - NTCP Polyclonal Antibody AP73555
    Western Blot analysis of A549 cells using NTCP Polyclonal Antibody.. Secondary antibody was diluted at 1:20000
  • 14 - NTCP Polyclonal Antibody AP73555
    Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
  • 14 - NTCP Polyclonal Antibody AP73555
    Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
  • 14 - NTCP Polyclonal Antibody AP73555
    Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P
Primary Accession Q14973
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 38119 Da
Additional Information
Gene ID 6554
Other Names SLC10A1; NTCP; GIG29; Sodium/bile acid cotransporter; Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1
Dilution WB~~Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
IHC-P~~Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name SLC10A1
Synonyms NTCP
Function As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It is strictly dependent on the extracellular presence of sodium (PubMed:14660639, PubMed:24867799, PubMed:34060352, PubMed:8132774). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:14660639, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (PubMed:33222321).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed in liver (PubMed:11031103, PubMed:12409283). Expressed in placental trophoblasts (PubMed:12409283).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The hepatic sodium/bile acid uptake system exhibits broad substrate specificity and transports various non-bile acid organic compounds as well. It is strictly dependent on the extracellular presence of sodium.

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