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SR-1E Polyclonal Antibody

     
  • 1 - SR-1E Polyclonal Antibody AP72577
    Western Blot analysis of various cells using SR-1E Polyclonal Antibody
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P28566
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 41682 Da
Additional Information
Gene ID 3354
Other Names HTR1E; 5-hydroxytryptamine receptor 1E; 5-HT-1E; 5-HT1E; S31; Serotonin receptor 1E
Dilution WB~~Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Format Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% (W/V) sodium azide.
Storage Conditions-20℃
Protein Information
Name HTR1E (HGNC:5291)
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). HTR1E is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731, PubMed:35610220).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in brain..
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

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