癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
K0415 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| IHC-P, E |
|---|---|
| Primary Accession | O43299 |
| Other Accession | Q3U829 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 88605 Da |
| Antigen Region | 294-322 aa |
| Gene ID | 9907 |
|---|---|
| Other Names | AP-5 complex subunit zeta-1, Adaptor-related protein complex 5 zeta subunit, Zeta5, AP5Z1, KIAA0415, SPG48 |
| Target/Specificity | This K0415 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-322 amino acids from the Central region of human K0415. |
| Dilution | IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | K0415 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | AP5Z1 |
|---|---|
| Synonyms | KIAA0415, SPG48 |
| Function | As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair. |
| Cellular Location | Cytoplasm. Nucleus. Note=By SDS-PAGE, 2 isoforms have been observed, the shorter seems to be predominantly nuclear and the longer is mostly cytoplasmic. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
The function of this protein has not been specifically defined.
REFERENCES
Hillier, L.W., et al. Nature 424(6945):157-164(2003)
Scherer, S.W., et al. Science 300(5620):767-772(2003)
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