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KLF2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, IHC-F, IF |
|---|---|
| Primary Accession | Q9Y5W3 |
| Reactivity | Human, Mouse, Rat, Rabbit, Sheep |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 37420 Da |
| Physical State | Liquid |
| Immunogen | KLH conjugated synthetic peptide derived from human KLF2 |
| Epitope Specificity | 251-355/355 |
| Isotype | IgG |
| Purity | affinity purified by Protein A |
| Buffer | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| SUBCELLULAR LOCATION | Nucleus. |
| SIMILARITY | Belongs to the krueppel C2H2-type zinc-finger protein family.Contains 3 C2H2-type zinc fingers. |
| SUBUNIT | Interacts with WWP1. |
| Post-translational modifications | Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. |
| Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| Background Descriptions | Kruppel-like factors (KLFs) are a family of broadly expressed zinc finger transcription factors. KLF2 regulates T-cell trafficking by promoting expression of the lipid-binding receptor S1P1 (S1PR1; MIM 601974) and the selectin CD62L (SELL; MIM 153240) (summary by Weinreich et al., 2009 [PubMed 19592277]).[supplied by OMIM, Feb 2011] |
| Gene ID | 10365 |
|---|---|
| Other Names | Krueppel-like factor 2, Lung krueppel-like factor, KLF2, LKLF |
| Dilution | WB=1:100-500,IHC-P=1:100-500,IHC-F=1:100-500,IF=1:100-500,Flow-Cyt=1ug/Test |
| Format | 0.01M TBS(pH7.4) with 1% BSA, 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| Name | KLF2 |
|---|---|
| Synonyms | LKLF |
| Function | Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription (PubMed:21063504). Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (PubMed:28167758). |
| Cellular Location | Nucleus. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Binds to the CACCC box in the beta-globin gene promoter and activates transcription (By similarity).
REFERENCES
Kozyrev S.V.,et al.FEBS Lett. 448:149-152(1999).
Wani M.A.,et al.Genomics 60:78-86(1999).
Lee H.J.,et al.Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
Conkright M.D.,et al.J. Biol. Chem. 276:29299-29306(2001).
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¥ 1,500.00
Cat# AP50863
