癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Synuclein γ Antibody
Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC |
|---|---|
| Primary Accession | O76070 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | polyclonal |
| Calculated MW | 13331 Da |
| Gene ID | 6623 |
|---|---|
| Other Names | Gamma-synuclein, Breast cancer-specific gene 1 protein, Persyn, Synoretin, SR, SNCG, BCSG1, PERSYN, PRSN |
| Dilution | WB~~ 1:1000 IHC~~1:50-1:100 |
| Format | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.09% (W/V) sodium azide and 50% glycerol. |
| Storage Conditions | -20℃ |
| Name | SNCG |
|---|---|
| Synonyms | BCSG1, PERSYN, PRSN |
| Function | Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity). |
| Cellular Location | Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle |
| Tissue Location | Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway (By similarity).
REFERENCES
Ji H.,et al.Cancer Res. 57:759-764(1997).
Ninkina N.N.,et al.Hum. Mol. Genet. 7:1417-1424(1998).
Lavedan C.,et al.Hum. Genet. 103:106-112(1998).
Han C.,et al.Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
Pronin A.N.,et al.J. Biol. Chem. 275:26515-26522(2000).
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