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>   首页   >   产品   >   一抗   >   微生物学   >   FUNDC2 Antibody (C-term)   

FUNDC2 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - FUNDC2 Antibody (C-term) AP20155b
    All lanes : Anti-FUNDC2 Antibody (C-term) at 1:500 dilution Lane 1: PC-3 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated (ASP1615) at 1/15000 dilution. Observed band size : 15kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - FUNDC2 Antibody (C-term) AP20155b
    FUNDC2 Antibody (C-term) (Cat. #AP20155b) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the FUNDC2 antibody detected the FUNDC2 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, E
Primary Accession Q9BWH2
Other Accession Q864V5, Q9D6K8, Q8MJN0, NP_076423.2
Reactivity Human, Rat, Mouse
Predicted Bovine, Pig
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 20676 Da
Antigen Region 122-150 aa
Additional Information
Gene ID 65991
Other Names FUN14 domain-containing protein 2, Cervical cancer proto-oncogene 3 protein, HCC-3, Hepatitis C virus core-binding protein 6, FUNDC2, HCBP6
Target/Specificity This FUNDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-150 amino acids from the C-terminal region of human FUNDC2.
Dilution WB~~1:1000
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.05% (V/V) Proclin 300. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFUNDC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FUNDC2 (HGNC:24925)
Synonyms HCBP6
Function Binds directly and specifically 1,2-Diacyl-sn-glycero-3- phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways (PubMed:29786068). May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes (PubMed:25855506, PubMed:29187281).
Cellular Location Mitochondrion outer membrane; Multi-pass membrane protein. Nucleus
Tissue Location Highly expressed in platelets (at protein level).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

The function of this protein is unknown.

REFERENCES

Olsen, J.V., et al. Cell 127(3):635-648(2006)
Li, K., et al. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 16(4):351-353(2002)
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

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