癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TBC1D20 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | Q96BZ9 |
| Other Accession | NP_653229.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 45855 Da |
| Antigen Region | 335-363 aa |
| Gene ID | 128637 |
|---|---|
| Other Names | TBC1 domain family member 20, TBC1D20, C20orf140 |
| Target/Specificity | This TBC1D20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 335-363 amino acids from the C-terminal region of human TBC1D20. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TBC1D20 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TBC1D20 (HGNC:16133) |
|---|---|
| Synonyms | C20orf140 |
| Function | GTPase-activating protein (GAP) specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude (PubMed:23236136). Also shows GAP activity for RAB18 GTPase (PubMed:26063829). Promotes RAB18 dissociation from the endoplasmic reticulum (ER) membrane into the cytosol, probably through stimulating RAB18 GTP-hydrolysis (PubMed:26063829). Involved in maintaining endoplasmic reticulum structure (PubMed:24891604). |
| Cellular Location | Membrane; Multi-pass membrane protein |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
TBC1D20 may act as a GTPase-activating protein for Rab family protein(s).
REFERENCES
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Sklan, E.H., et al. J. Biol. Chem. 282(50):36354-36361(2007)
Sklan, E.H., et al. J. Virol. 81(20):11096-11105(2007)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
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¥ 1,250.00
Cat# AP18652b
