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>   首页   >   产品   >   一抗   >   代谢   >   ALDH6A1 Antibody (N-term)   

ALDH6A1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • 1 - ALDH6A1 Antibody (N-term) AP1469A
    Anti-ALDH6A1 Antibody (N-term) at 1:1000 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 58 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • 1 - ALDH6A1 Antibody (N-term) AP1469A
    Western blot analysis of ALDH6A1 Antibody (N-term) (Cat.#AP1469a) in T47D cell line lysates (35ug/lane). ALDH6A1 (arrow) was detected using the purified Pab.
  • 14 - ALDH6A1 Antibody (N-term) AP1469A
    Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with *ALDH6A1 antibody (N-term) (Cat.#AP1469a), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • 4 - ALDH6A1 Antibody (N-term) AP1469A
    Flow cytometric analysis of ATDC5 cells using ALDH6A1 Antibody (N-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB, IHC-P, FC, E
Primary Accession Q02252
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 57840 Da
Antigen Region 30-59 aa
Additional Information
Gene ID 4329
Other Names Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial, MMSDH, Malonate-semialdehyde dehydrogenase [acylating], Aldehyde dehydrogenase family 6 member A1, ALDH6A1, MMSDH
Target/Specificity This ALDH6A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-59 amino acids from the N-terminal region of human ALDH6A1.
Dilution WB~~1:1000
IHC-P~~1:100~500
FC~~1:10~50
E~~Use at an assay dependent concentration.
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALDH6A1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALDH6A1 (HGNC:7179)
Function Malonate and methylmalonate semialdehyde dehydrogenase involved in the catabolism of valine, thymine, and compounds catabolized by way of beta-alanine, including uracil and cytidine.
Cellular Location Mitochondrion.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

ALDH6A1 belongs to the aldehyde dehydrogenases family of proteins. This enzyme plays a role in the valine and pyrimidine catabolic pathways. This protein is a mitochondrial methylmalonate semialdehyde dehydrogenase, and catalyzes the irreversible oxidative decarboxylation of malonate and methylmalonate semialdehydes to acetyl- and propionyl-CoA. Methylmalonate semialdehyde dehydrogenase deficiency is characterized by elevated beta-alanine, 3-hydroxypropionic acid, and both isomers of 3-amino and 3-hydroxyisobutyric acids in urine organic acids.

REFERENCES

Kuiper,H., Cytogenet. Genome Res. 109 (4), 533 (2005)
Anderson,N.L., Mol. Cell Proteomics 3 (4), 311-326 (2004)
Chambliss,K.L., J. Inherit. Metab. Dis. 23 (5), 497-504 (2000)
Kedishvili,N.Y., J. Biol. Chem. 267 (27), 19724-19729 (1992)

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