癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
DPYSL3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q14195 |
| Other Accession | Q62952, Q62188, NP_001378.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 61963 Da |
| Antigen Region | 461-490 aa |
| Gene ID | 1809 |
|---|---|
| Other Names | Dihydropyrimidinase-related protein 3, DRP-3, Collapsin response mediator protein 4, CRMP-4, Unc-33-like phosphoprotein 1, ULIP-1, DPYSL3, CRMP4, DRP3, ULIP, ULIP1 |
| Target/Specificity | This DPYSL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 461-490 amino acids from the C-terminal region of human DPYSL3. |
| Dilution | WB~~1:1000 IHC-P~~1:100~500 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DPYSL3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DPYSL3 |
|---|---|
| Synonyms | CRMP4, DRP3, ULIP, ULIP1 |
| Function | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity). |
| Cellular Location | Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone. |
| Tissue Location | Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity).
REFERENCES
Okita, K., et al. Cancer Sci. 101(11):2333-2340(2010)
Gao, X., et al. Oncogene 29(32):4555-4566(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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