ABI2 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application ![]()
| WB |
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Primary Accession | Q9NYB9 |
Other Accession | NM_005759, NP_005750 |
Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Dog, Guinea Pig, Horse, Bovine, Yeast |
Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine, Yeast |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 55663 Da |
Gene ID | 10152 |
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Alias Symbol | ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBPIA, argBPIB |
Other Names | Abl interactor 2, Abelson interactor 2, Abi-2, Abl-binding protein 3, AblBP3, Arg-binding protein 1, ArgBP1, ABI2, ARGBPIA |
Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ABI2 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
Precautions | ABI2 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABI2 {ECO:0000303|PubMed:28397838, ECO:0000312|HGNC:HGNC:24011} |
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Function | Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as a regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:10498863, PubMed:7590236, PubMed:8649853). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692). |
Cellular Location | Cytoplasm. Nucleus |
Tissue Location | Widely expressed. Abundant in testes, ovary, thymus, and colon, with lower but detectable levels in prostate, peripheral blood leukocytes, and spleen. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Dai Z.,et al.Genes Dev. 9:2569-2582(1995).
Ren R.,et al.Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Wang B.,et al.Oncogene 12:1921-1929(1996).
Kalnine N.,et al.Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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