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>   首页   >   产品   >   一抗   >   免疫学   >   FCRL5 Antibody - C-terminal region   

FCRL5 Antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • 1 - FCRL5 Antibody - C-terminal region AI14582

    WB Suggested Anti-FCRL5 Antibody Titration: 1.0 μg/ml
    Positive Control: Fetal Small Intestine
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession Q96RD9
Other Accession NM_031281, NP_112571
Reactivity Human
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 106437 Da
Additional Information
Gene ID 83416
Alias Symbol BXMAS1, CD307, DKFZp667E2019, DKFZp667F216, FCRH5, FLJ00333, FLJ00397, IRTA2, MGC119590, MGC119592, MGC119593, PRO820
Other Names Fc receptor-like protein 5, FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, FcRH5, Immune receptor translocation-associated protein 2, CD307e, FCRL5, FCRH5, IRTA2
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-FCRL5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsFCRL5 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FCRL5
Synonyms FCRH5, IRTA2
Function Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (PubMed:30107486). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

Nakayama Y.,et al.Biochem. Biophys. Res. Commun. 285:830-837(2001).
Hatzivassiliou G.,et al.Immunity 14:277-289(2001).
Davis R.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 98:9772-9777(2001).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Bechtel S.,et al.BMC Genomics 8:399-399(2007).

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