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>   首页   >   产品   >   一抗   >   基因重组   >   Anti- FcRH5 / IRTA2 / CD307e Reference Antibody (DFRF4539A)   

Anti- FcRH5 / IRTA2 / CD307e Reference Antibody (DFRF4539A)

Recombinant Antibody

     
  • 1 - Anti- FcRH5 / IRTA2 / CD307e Reference Antibody (DFRF4539A) APR10760
    Anti- FcRH5 / IRTA2 / CD307e Reference Antibody (DFRF4539A) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%
  • 1 - Anti- FcRH5 / IRTA2 / CD307e Reference Antibody (DFRF4539A) APR10760
    The purity of Anti- FcRH5 / IRTA2 / CD307e Reference Antibody (DFRF4539A)is more than 95% ,determined by SEC-HPLC.
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
FC, Kinetics, Animal Model
Primary Accession Q96RD9
Reactivity Human
Clonality Monoclonal
Isotype IgG1
Calculated MW 106437 Da
Additional Information
Target/Specificity FcRH5 / IRTA2 / CD307e
Endotoxin < 0.001EU/ µg,determined by LAL method.
Conjugation Unconjugated
Expression system CHO Cell
Format Purified monoclonal antibody supplied in PBS, pH6.0, without preservative.This antibody is purified through a protein A column.
Protein Information
Name FCRL5
Synonyms FCRH5, IRTA2
Function Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (PubMed:30107486). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed in marginal zone B-cells, immunoblasts, tonsillar germinal center centrocytes and in the intraepithelial and interfollicular regions of the tonsil. Expressed in many lymphoma cell lines and on hairy cell leukemia cells. Isoform 1, isoform 3, isoform 4 and isoform 5 are detected in lymph node, spleen, bone marrow, and small intestine with preponderance of isoform 3. Expressed in mature and memory B-cells and down-regulated in germinal center cells (at protein level).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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