癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Cpne6 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9Z140 |
| Other Accession | NM_009947, NP_034077 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine, Sheep |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 61781 Da |
| Gene ID | 12891 |
|---|---|
| Alias Symbol | AU067659, BB076446 |
| Other Names | Copine-6, Copine VI, Neuronal-copine, N-copine, Cpne6 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-Cpne6 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | Cpne6 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Cpne6 {ECO:0000312|MGI:MGI:1334445} |
|---|---|
| Function | Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (PubMed:9886090). Plays a role in dendrite formation by melanocytes (By similarity). |
| Cellular Location | Cytoplasm. Cell membrane. Endosome. Cytoplasmic vesicle, clathrin-coated vesicle. Perikaryon. Cell projection, dendrite. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium (PubMed:9886090). Translocates to the cell membrane in a calcium- dependent manner (PubMed:21087455, PubMed:26175110). Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner (PubMed:21087455) |
| Tissue Location | Expressed in the brain (PubMed:9645480). Expressed in pyramidal cells, granule cells, and neurons in the dentate gyrus of the hippocampus and in granule cells of the olfactory bulb (at protein level). Expressed in pyramidal cells of the CA1-CA3 regions, in granule cells of the dentate gyrus, in granule cells of the olfactory bulbs, in the mitral cell layer and in neurons of the cerebral cortex layer II, brainstem and spinal cord (PubMed:9886090). Not detected in glial cells (PubMed:9645480, PubMed:9886090). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Nakayama T.,et al.FEBS Lett. 428:80-84(1998).
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