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GPNMB antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 文献引用 : 1
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q14956 |
| Other Accession | NM_002510, NP_002501 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Pig, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 63923 Da |
| Gene ID | 10457 |
|---|---|
| Alias Symbol | HGFIN, NMB |
| Other Names | Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, GPNMB, HGFIN, NMB |
| Target/Specificity | 100% homologous to both isoforms of hGPNMB |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-GPNMB antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | GPNMB antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GPNMB |
|---|---|
| Synonyms | HGFIN {ECO:0000303|PubMed:12609765}, NMB |
| Function | Could be a melanogenic enzyme. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein Melanosome membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV |
| Tissue Location | Widely expressed, but very low expression, if any, in the brain (PubMed:12609765, PubMed:16609006). Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) (PubMed:29336782). Expressed in peripheral blood, but not bone marrow mononuclear cells (PubMed:12609765). Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) (PubMed:16489096). May be overexpressed in various cancers, including melanoma and glioblastoma multiforme (PubMed:16489096, PubMed:16609006, PubMed:7814155). |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Oh,J.H.,(2005)Mamm.Genome16(12),942-954ReconstitutionandStorage:Forshorttermuse,storeat2-8Cupto1week.Forlongtermstorage,storeat-20Cinsmallaliquotstopreventfreeze-thawcycles.
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