癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TSG101 antibody - middle region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q61187 |
| Other Accession | NM_021884, NP_068684 |
| Reactivity | Human, Mouse, Rat, Rabbit, Goat, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Chicken, Goat, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44124 Da |
| Gene ID | 22088 |
|---|---|
| Alias Symbol | CC2, AI255943 |
| Other Names | Tumor susceptibility gene 101 protein, ESCRT-I complex subunit TSG101, Tsg101 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-TSG101 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TSG101 antibody - middle region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Tsg101 |
|---|---|
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q99816}. Early endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99816}. Late endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99816}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q99816}. Nucleus {ECO:0000250|UniProtKB:Q99816}. Note=Mainly cytoplasmic. Membrane- associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis {ECO:0000250|UniProtKB:Q99816} |
| Tissue Location | Ubiquitous. Higher expression in brain and mammary gland. Lower expression in liver and tumoral tissues |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Stefan,M., (er) BMC Genomics 6, 157 (2005)Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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