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细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
TLE3 antibody - N-terminal region
Rabbit Polyclonal Antibody
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q04726 |
| Other Accession | Q04726, NP_005069, NM_005078 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Chicken, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 83417 Da |
| Gene ID | 7090 |
|---|---|
| Alias Symbol | ESG, ESG3, GRG3, HsT18976 |
| Other Names | Transducin-like enhancer protein 3, Enhancer of split groucho-like protein 3, ESG3, TLE3, KIAA1547 |
| Target/Specificity | The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. These genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway which controls a number of different cell-fate choices in invertebrates and vertebrates. |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-TLE3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | TLE3 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TLE3 {ECO:0000303|PubMed:28689657, ECO:0000312|HGNC:HGNC:11839} |
|---|---|
| Function | Transcriptional coregulator that binds to a number of transcription factors. Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG (PubMed:28689657). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (PubMed:28689657). Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (By similarity). |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q08122}. Note=Localizes to chromatin {ECO:0000250|UniProtKB:Q08122} |
| Tissue Location | Placenta and lung.. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This is a rabbit polyclonal antibody against TLE3. It was validated on Western Blot using a cell lysate as a positive control. Abgent strives to provide antibodies covering each member of a whole protein family of your interest. We also use our best efforts to provide you antibodies recognize various epitopes of a target protein. For availability of antibody needed for your experiment, please inquire (sales@abgent.com).
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