Anti-ZNT2 Antibody

Immunohistochemical analysis of ZNT2 staining in human lung cancer formalin fixed paraffin embedded tissue section.
WB analysis of ZNT2 expression in HeLa (A); RAW264.7 (B); PC12 (C) whole cell lysates.

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC
Primary Accession	Q9BRI3
Reactivity	Human, Mouse, Rat
Host	Rabbit
Isotype	Rabbit IgG
Calculated MW	40564 Da

Additional Information
Gene ID	7780
Positive Control	WB: HeLa, RAW264.7, PC12 cell lystae; IHC: human lung cancer
Application & Usage	WB; 1:500 – 1:2000, IHC; 1:50 – 1:200
Other Names	ZNT2, Zinc transporter 2, ZnT-2, Solute carrier family 30 member 2
Target/Specificity	SLC30A2
Antibody Form	Liquid
Appearance	Colorless liquid
Handling	The antibody solution should be gently mixed before use
Reconstitution & Storage	-20°C
Background Descriptions
Precautions	Anti-ZNT2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	SLC30A2 (HGNC:11013)
Function	[Isoform 1]: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:17065149, PubMed:21289295, PubMed:22733820, PubMed:25657003, PubMed:25808614, PubMed:30893306). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (PubMed:19496757). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (PubMed:25808614).
Cellular Location	[Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane; Multi-pass membrane protein. Zymogen granule membrane {ECO:0000250\|UniProtKB:Q2HJ10}; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Mitochondrion inner membrane; Multi-pass membrane protein. Note=Localization to lysosomes is induced by TNF