癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Vaspin
- 产品详情
- 实验流程
| Primary Accession | Q8IW75 |
|---|---|
| Species | Human |
| Sequence | Leu21-Lys414 |
| Purity | > 95% as analyzed by SDS-PAGE > 95% as analyzed by HPLC |
| Endotoxin Level | < 0.2 EU/ µg of protein by gel clotting method |
| Expression System | E. coli |
| Formulation | Lyophilized after extensive dialysis against PBS. |
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O up to 100 µg/ml. |
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Gene ID | 145264 |
|---|---|
| Other Names | Serpin A12, OL-64, Visceral adipose tissue-derived serine protease inhibitor, Vaspin, Visceral adipose-specific serpin, SERPINA12 |
| Target Background | Vaspin is a cytokine originally identified in visceral adipose tissue of Otsuka Long-Evans Tokushima fatty rats, and the name “Vaspin” is short for visceral adipose tissue-derived serine protease inhibitor. Besides the visceral adipose, Vaspin is also expressed in the skin, hypothalamus, pancreatic islets and stomach, and is shown to exert an anti-inflammatory role by inhibiting several proinflammatory adipokines such as leptin, resistin, and Tumor Necrosis Factor-α. Vaspin also stimulates adiponectin expression and improves insulin sensitivity in mice. Vaspin expression has been shown to decrease with worsening of diabetes and body weight loss. Accordingly, administration of recombinant human Vaspin improved glucose tolerance in diet regulated mice suggesting it as a potential target for obese-related diseases. |
| Name | SERPINA12 |
|---|---|
| Function | Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed in visceral adipose tissues. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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